Saint Francis de Sales Roman Catholic Church is located at 407 Northland Ave, in Buffalo, New York.

The Italian Romanesque Revival style church previously served as a parish of the Roman Catholic Diocese of Buffalo.

[1] The exterior of the church was built of Indiana limestone, with no structural steel being used in the construction of the building's shell.

[2] While operated by the Roman Catholic Diocese of Buffalo, the church contained a Teller-Kent organ.

In 2003, the church was purchased at auction by the Reverend Perry Davis, after having been flipped several times and pillaged.