The history of St. George's Girls School stretches back to 1884, when Mrs. Biggs, wife of the British colonial chaplain, Rev.

Biggs, the colonial chaplain at Penang's first Anglican church, after St. George, the martyr, who was the patron saint of England (as well as of a number of other kingdoms, including Catalonia, Ethiopia, Greece and Palestine).

[9] The decade after World War I was a benchmark in the evolution of the educational curriculum which originally consisted of reading, writing and mathematics, and the expansion of extra-curricular activities.

In July 1934, a debate was held under the auspices of the Penang Teachers' Association on the topic "Women's Place is in the Home".

[12][13] During the reconstruction after the war, the students worked hard to restore the school's reputation, achieving 100% pass rate in the Cambridge examinations, for 1946, 1947 and 1948.

Due to the Ministry of Education's emphases on early preparation of science education starting at the high school level, the national supply of local medical graduates (resulting in 1 doctor for every 454 persons in the country in 2020, which exceeded the World Health Organization's recommendation of 1 doctor for every 500 persons), has exceeded the number of permanent employment positions available in the country's public healthcare system.