Sekolah Menengah Sains Rembau (English: Rembau Science Secondary School; abbreviated SEMESRA) is a co-educational secondary school situated in the district of Rembau and among fully residential schools (Sekolah Berasrama Penuh) in the state of Negeri Sembilan, Malaysia.

[1] On 30 October 2014, SEMESRA was awarded with the Sekolah Berprestasi Tinggi or High Performance School title.

[2] Sekolah Menengah Sains Rembau, Negeri Sembilan (SEMESRA) was established on 1 October 2009.

He was assisted by the Vice Principals; Baharudin Husin (Academics), Azman Awang (Student Affairs), and Roslina Aziz (Co-curriculum).

[3] In 2012, with a GPS of 1.0408, 119 out of 150 students received straight A's in the PMR 2011 examinations, allowing SEMESRA to be ranked in the 9th spot nationwide and became the second best school in Negeri Sembilan that year.