In 1275, one Olof Blok willed the contents of a house in Copenhagen for the maintenance of the leper hospital.
The hospital consisted of living quarters, a chapel, farm buildings and a brewery for the use of the inmates.
During the reign of Hans I of Denmark, the hospital became crown property and in 1502 it was given to Peder Andersen, a chancellor of the University of Copenhagen.
The situation was remedied in 1508 when he ordered the income from the hospital restored for the use of the "unhappy folk and sick".
He also ordered two offering chests to be set up in the chapel which only the superintendent in the presence of one of the lepers could open.
St. George's survived the Reformation, though the property reverted to the crown at some point, and was later administered by a superintendent appointed by the Copenhagen City Council.