In the 19th century Catholic Armenians from Western Armenia, mainly from the towns and cities of Karin (Erzurum), Constantinople, Mardin etc., came to the United States seeking employment.

Catholic Armenian communities were also founded in New Jersey, Boston, Detroit, Los Angeles, and other cities of California.

Raphaël Minassian was appointed to the mission in Los Angeles in 1989, taking up residence at Our Lady Queen of Martyrs.

Bishop Manuel Batakian, the Exarch of Armenian Catholics in the United States and Canada, consecrated the church on March 18, 2001.

In 2005, by Pope Benedict XVI's decision, the Catholic Exarchate of the USA and Canada was advanced to the status of a diocese.

According to a Monday, May 23, 2011, news release by the United States Conference of Catholic Bishops, Pope Benedict XVI, named Archpriest Mikaël Antoine Mouradian, superior of the Convent of Notre Dame in Bzommar, Lebanon, as the new bishop of the Eparchy of Our Lady of Nareg in New York for Armenian Catholics.

The appointment of Lebanon-born Bishop Mouradian was publicized in Washington, May 21, by Archbishop Pietro Sambi, Apostolic Nuncio to the United States.