The St. Joe Blacksnakes, in Saint Joseph, Missouri, were a member of the American Association of Independent Professional Baseball.

On December 16, 2005 the team announced that the primary owner would be Van Schley and that the field manager would be Chris Carminucci.

On December 27, St. Joe acquired its first player — outfielder Jake Whitesides from New Jersey.

St. Joseph played its first home game against the Sioux Falls Canaries on May 19, 2006, at Phil Welch Stadium.

Following the addition of two new teams to the league and the cease of operations of the Coastal Bend Aviators, the Blacksnakes disbanded after the 2007 season.