The property, on which the present church also stands, was a gift from Josiah Spalding of St. Louis.

Included in their number were Generals Samuel Ryan Curtis, who was serving as a congressman at the time, Hugh Thompson Reid, James C. Parrott, and William W. Belknap, who was later Secretary of War under President Ulysses S. Grant.

"No other city in Iowa furnished as many high ranking officers as did Keokuk, and no other church could boast as many regimental commanders and generals from (its) membership.

"[2] The present church building was designed by Boston architects Appleton & Stephenson.

Work was begun on the structure on June 5, 1884, and the first services were held in the church on February 12, 1888.

The church is a combination of Gothic Revival in its style and Richardsonian Romanesque in its form and massing.

The interior of the church contains hand-carved furnishings by William Bartels of Carthage, Illinois.

The three panels on the front of the altar depict grapes and wheat to represent the Eucharist, and a bas relief of Christ carrying the cross.

The baptismal font, carved by William Bawden in limestone, is the only item in the interior from the original church.