Located on a 12-acre (4.9 ha) site near the foothills of Camarillo, the hospital was built with five acres that were donated originally by the Berylwood Investment Company.

James P. Lockett designed the facility using a hexagon shape first seen in early Roman architecture.

[3] That same year, the hospital reached full occupancy of its 46 beds for the first time since opening.

[3] In 1993, Pleasant Valley Hospital in Camarillo became known as St. John's Pleasant Valley Hospital, after it merged with St. John's Regional Medical Center in Oxnard.

The hospital added technology including wound treatment, hyperbaric medicine oxygen chambers, and diagnostic imaging equipment.