The school is located on a 38-acre (150,000 m2) campus in Holmdel Township, in Monmouth County, in the U.S. state of New Jersey, and is operated under the supervision of the Roman Catholic Diocese of Trenton.

[17] The 1978 boys' basketball team came into the playoffs with a 12-12 record and went on to win the Non-Public Group B state title, defeating runner-up Our Lady of the Valley High School by a score of 65-58 in the tournament final.

[21] In 2014, St. John Vianney's baseball team defeated Gloucester Catholic High School by a score of 3-2 to win the NJSIAA Non-Public South A sectional final and won the state Non-Public A title as an 8 seed in their own section when they defeated St. Joseph Regional High School, the representative from North A by a score of 3-1 in the state championship gane.

[22] The girls' tennis team won the Non-Public A state championship in 1988, defeating runner-up Academy of the Holy Angels in the final match of the tournament.

[25] In 2005, the girls' basketball team won the Non-Public, South A title over Red Bank Catholic High School, 51-39.

[28] In 2008, the girls' basketball team won the Parochial A state championship and moved on to lose in the Tournament of Champions semifinals to Malcolm X Shabazz High School by a score of 75-35.

[29] In 2009, the Lady Lancer basketball team, led by Coach Dawn Karpell, won the Non-Public A title with a 77-46 win against Immaculate Heart in the finals at the Ritacco Center in Toms River[30] and was ranked #1 in the New York Metropolitan region by the MSG network after winning their record sixth Tournament of Champions title, defeating Colts Neck by a score of 56-44 in the tournament final.

[32] The Lady Lancers lost to Neptune High School by a score of 67-48 in the finals of the Tournament of Champions at the Izod Center.

[34] The 2000 girls' soccer team won the Parochial South A state championship, defeating Holy Cross High School 4-0 in the tournament final.

[39] The 2004 team repeated as sectional champion, with a 5-0 shutout of Red Bank Catholic High School and moved on to win the Group A state championship with a 1-0 win over Mount Saint Dominic Academy, the lone run coming in the bottom of the seventh due to an error on a bunt that allowed a runner to score from second base.

[40][41] The 2004 team finished the season with a perfect 33-0 record, setting the state mark for the number of wins in a season by a girls' softball team, and gave the Lady Lancers three state titles in four years, the only exception being an extra innings loss in the 2003 tournament final to Immaculate Heart Academy.