St. Johnsbury is a census-designated place (CDP) corresponding to the main settled areas in the town of St. Johnsbury, Caledonia County, Vermont, United States.

The CDP is in eastern Caledonia County, occupying the southern one-third of the town of St. Johnsbury.

It includes the urban center of St. Johnsbury, the village of St. Johnsbury Center to the north up the valley of the Passumpsic River, and development along Route 2 to the east up the valley of the Moose River, but not as far as the village of East St. Johnsbury.

Interstate 91 passes through the west side of the CDP, with access from Exits 20, 21, and 22.

U.S. 2 leads west 35 miles (56 km) to Montpelier, the state capital, and east 28 miles (45 km) to Lancaster, New Hampshire, while U.S. 5 provides a local parallel route to I-91, leading north 8 miles (13 km) to Lyndonville and south 20 miles (32 km) to Wells River.