Italian Jesuit missionary Carlo Giovanni Turcotti [no] was appointed as its bishop, however, he never entered Guiyang.

However, Visdelou was not able to enter Guizhou due to prohibitions against foreign missionaries created by the Kangxi Emperor.

In 1798, a small church was created by Lawrence Hu Shï-lu (胡世祿), a Sichuanese priest, for the Catholic community of about 100 people, however, this was later destroyed during the persecution under the Jiaqing Emperor in 1811.

Albrand invoked the 1844 Treaty of Whampoa to demand that local authorities return the land of the former church.

In 1874, the current structure of the cathedral was erected under the supervision of François-Eugène Lions [zh], Apostolic Vicar of Guizhou.