Co-curricular and sports activities are governed by the Mississippi Association of Independent Schools (MAIS).

St. Joseph is accredited by the Southern Association of Colleges and Schools (SACS) and by the Mississippi Department of Education.

The history of St. Joseph Catholic School began with St. Rose of Lima Academy, founded by Father P.J.

Located next to the St. Joseph Parish Church, St. Rose was the standard for Catholic education in the Delta for sixty-two years.

By 1949 the enrollment had exceeded the space of the building, and St. Joseph Elementary and High School were opened in 1950.