Vicksburg Catholic School is a private, Roman Catholic high school in Vicksburg, Mississippi.

It is located in the Roman Catholic Diocese of Jackson.

It includes the following campuses: St. Francis Xavier Academy was established in 1860 by the Sisters of Mercy.

St. Aloysius was founded in 1879 by the Brothers of the Sacred Heart.

In 1906 St. Mary's School was established by Sisters of the Divine Word.