St. Leo's College, Kyegobe is a Catholic-based, government-aided residential boys' secondary school, located in Fort Portal, Kabarole District, in the Western Region of Uganda.

In the early 1960s, the school was shifted to its current location, on a hill overlooking the plains of the Rwenzori Mountains and some parts of Fort Portal town.

[7] St. Leo's College was, at one time, among the most prestigious schools in Uganda because of its history, influence, excellent academic performance, and dominance in sports.

[10][11] Subjects offered at "O" Level include biology, chemistry, Christian religious education, commerce, computer studies, English language and literature, fine art, French, geography, history, mathematics, and physics.

[3] The following notable people are alumni of St. Leo's Kyegobe:[12] (1) Crescent Baguma, (2) Venansius Baryamureeba, (3) Tress Bucyanayandi, (4) Tom Butime (5) John Byabagambi (6) Joseph Mulenga (8) Charles Onyango-Obbo and (9) Shaban Bantariza[13] (10) Dr. Paul Kawanga Ssemogerere (11) Selestino Babungi (12) Herbert Kiiza (13) Abaine Jonathan Bulegyeya (14) Dr. Silver Mugisha.