On April 26, 2003, St. Louis played its first national match at Chicago's Gaelic Park, defeating the University of Notre Dame 3-9 (19) to 2-3 (9).

NACB is overseen by the Gaelic Athletic Association (GAA), the governing body of hurling at its top level in Ireland.

In the Championship they defeated a tough Buffalo side by a score of 2–4 to 0-8 and won by a late goal by club legend John Behl.

In addition to their representative side, they regularly join forces with other clubs in the Midwest to send teams overseas: most recently, in 2013 the "Heartland Hurlers", composed of top players from St Louis, Indianapolis and Kansas City, traveled to Ireland for a week of training and competition with sides from Kilkenny, Limerick and Tipperary, finishing with a tournament in Thurles where "the Interstate 70 Boys" reached the semi-finals and received recognition from Irish TV when the group was shown during a match at Semple Stadium.

The St. Louis Gaelic Athletic Club (STLGAC) participated in the Fitzgerald Recruitment GAA World Games 2023 held at the Owenbeg Centre of Excellence in Dungiven, Derry.

Alongside their Spring and Autumn leagues, the Club stays committed to representing the city in national competitions, festivals, and exhibition matches to promote the popularity of Hurling, Gaelic Football, and Camogie in St. Louis and across the country.