In 1881, the school was relocated to Beretania Street, in downtown Honolulu, adjacent to Washington Place, the home of Liliuokalani, who was Queen of Hawaii from 1891 to 1893.

In 1883, the school moved again for a third time to Kamakela (known today as College Walk), on the bank of the Nuʻuanu Stream, near Chinatown, Honolulu.

Marianists assumed control of the school and determined a need to expand facilities to serve the burgeoning Hawaiian Catholic population, who included many Filipino immigrants.

Because of the Marianist core mission to educate regardless of ethnic, religious, or fiscal means, the Order purchased land in Kalaepōhaku, a hillside division of Honolulu's Kaimuki community, to enable the school to better serve Hawaii.

Saint Louis School also fields teams in bowling, cross country, kayaking, and water polo in the fall.

Saint Louis has had a strong history in Football winning a total of fourteen Oahu State Prep Bowls, in 1983 and consecutively from 1986 to 1998.

Saint Louis also won Hawaii state basketball championships in 1968 and 1986 with Kaipo Johnston Spencer first as a player in ‘68 then later as coach of the ‘86 team.