St. Louis Senior High School is a Ghanaian educational institution for girls in the Oduom suburb of Kumasi in the Ashanti Region.

The people now begin to realize that more must be done in favour of this much–neglected part of the human race, and the chiefs, conscious of their duty towards their subjects, asked us to establish schools for girls in their respective villages….

But to obtain results, it is necessary that the direction of girls' schools should be in the hands of 'Sisters of a Teaching Order' with the necessary experience in the latest development of pedagogic methods.

The church wanted the Apostolate of Education to develop the essential task of forming strong and enlightened Christians, capable of exercising much influence in social and political affairs.

It was upon these commendations that the Ministry of Education, in 1960, wished the Sisters would open a Training College on the site on which St. Louis Secondary School now stands.

The foundation stone was laid by Otumfuo Osei Agyemang Prempeh II, Asantehene, on 25 March 1960 (the feast of Annunciation) and was blessed by Andrew van den Bronk (SMA), Bishop of Kumasi.

To attend the shortage of missionary priests and nuns, the students formed a strong lay apostolate to go to the outlying compounds to teach catechism, prepare candidates for baptism, and visit lapsed Christians to persuade them to return.