The hospital was founded in 1884[1] by the Protestant Episcopal church with significant financial contributions from Horatio Hathaway, a church leader and one of the founders of Berkshire Hathaway.

[2] In 1996, St. Luke's merged with Charlton Memorial[3] in Fall River and Tobey Hospital[4] in Wareham to form the Southcoast Health System.

In 2006, St. Luke's began constructing a new Emergency Department, which includes nineteen new private treatment bays.

In 2008, the In-House Patient Pharmacy Department installed a drug dispensing system throughout the floors called Pyxis Connect.

St. Luke's has 293 beds in service and offers in-patient medical and surgical services,[5] including neurosurgery, cardiology, pediatric care, orthopedics, and general surgery.