[3] The Coptic families in Los Angeles started settling from around the late 1960s when the late Father Bishoy Kamel was commissioned to serve the church in 1969,[4] during Pope Cyril VI's papacy.

Bishoy was a prominent Copt, being considered a modern-day saint within the Church, and helped to found not only St. Mark's but several other parishes and buildings throughout Egypt, the United States, Europe and Australia.

[5] The congregation initially used a Syriac Orthodox building to accommodate its liturgies.

Then, the congregation eventually purchased the current building which was previously used by the Russian Orthodox.

[6] Several years later, in 1995, the Coptic Orthodox Diocese of Los Angeles, Southern California and Hawaii was founded.