The first to raise the possibility of St. Mary's becoming a cathedral was Bishop John Yanta.

The present church was dedicated on September 11, 2010, and it was proclaimed as the third cathedral of the Amarillo Diocese on March 25, 2011.

[3] Documentation shows that the relics are from St. Thomas Aquinas, St. John Vianney and St. Pius X.

Original works of art include the tapestries from Taos, New Mexico and a baptismal pool made of copper by an artist from South Texas.

[3] On the exterior of the cathedral is a bas relief in the brick of Virgin Mary with the Christ Child.