It was founded by Comboni Missionaries and is administered and managed by Roman Catholic Archdiocese of Gulu.

The hospital maintains remote Level III Health Centers in Amuru, Opit and Pabbo with an additional 24 beds.

Each day the hospital hosts an average of 600 inpatients and their attendants, as well as 500 outpatients, for a daily total of about 2,000 individuals.

Throughout the 1980s, the hospital remained at constant risk as thugs repeatedly ransacked the compound, looking for drugs or petrol.

Other notable employees include Matthew Lukwiya, who was instrumental in containing a 2000 outbreak of Ebola, before succumbing to the disease himself.