St. Mary's Regional Medical Center is a hospital located in Enid, Oklahoma.

Ownership and operations were transferred to the Sisters Adorers of the Precious Blood on June 1, 1937.

The hospital trained nurses at Enid High School from 1915 to 1951, and at Phillips University from 1971 to 1973.

[2] On October 11, 1973, Boggy Creek flooded the hospital and parking lots, after 17 inches of rain fell within 8 hours.

[1] The hospital is currently owned by Universal Health Services, since 2000, having previously leased it from the Adorers in 1985.