One of St. Mary's more notable patients was New York City Mayor William Jay Gaynor, who was shot on August 9, 1910, as he boarded the SS Kaiser Wilhelm der Grosse at the Hoboken piers.

The assailant was James J. Gallagher, who had been fired from his job in the New York City Docks Department and who blamed the mayor for his troubles.

Care facilities at the hospital include Emergency Services, Oncology, Orthopedic, Hemodialysis, Obstetrics, Nuclear Medicine, Rehab/Physical therapy, ICU, Psychiatry, Skilled Nursing, and Inpatient Surgery/Robotic surgery.

[9] Hoboken University Medical Center is one of 332 national US hospitals with the lowest CAUTI rates (catheter associated urinary tract infections) from data collected in 2019.

[12] Hoboken University Medical Center has earned the Joint Commission's Gold Seal of Approval for Hospital Accreditation.

After nearly 140 years of operation, St. Mary Hospital was sold to the Bon Secours Health System, Inc. in 2000 by the Franciscan Sisters of the Poor, who had split off from the German congregation.

That following year, Bon Secours formed a partnership with Canterbury Health, a company that owned the Episcopalian-affiliated Christ Hospital in Jersey City at the time.

[20] In November 2024, CarePoint Health filed for Chapter 11 bankruptcy protection, blaming high rising costs and lack of state funding from New Jersey.