[2]: 45  Located north of U.S. Route 33 between St. Marys and Wapakoneta,[2]: 45  the church was built in 1883 in the Gothic Revival style.

[3]: 3, 7  Mass was celebrated in private homes until a leading member donated land for a cemetery and church, which was built in 1860.

[5] Starting in the 1840s, the church was served by priests of the Society of the Precious Blood who were based at Minster,[3]: 7, 8  approximately 15 miles (24 km) to the south.

[2]: 45, 55 During the 1870s, Six Mile prospered due to the discovery of oil and natural gas in the region and the coming of the Lake Erie and Western Railroad; when the railroad built a depot in Six Mile, it renamed the community for local resident John Glynn.

[7] Architectural historians have divided the Precious Blood-related churches of western Ohio into multiple generations.