St. Paul is a town in Madison County, Arkansas, United States.

Arkansas Highways 16 and 23 run through the town together as 5th Street and Madison Avenue.

The north boundary of the Ozark-St. Francis National Forest is adjacent to the south side of the community.

The ecoregion is generally higher and moister than the Lower Boston Mountains; elevations vary from 1,900 to 2,800 feet (580 to 850 m).

The region is underlain by Pennsylvanian sandstone, shale and siltstone that contrasts with the limestone and dolomite that dominates the Ozark Highlands.

Water quality in streams reflects geology, soils, and land use, and is typically exceptional; mineral, nutrient, and solid concentrations as well as turbidity all tend to be very low.

About 12.5% of families and 16.9% of the population were below the poverty line, including 32.4% of those under the age of eighteen and 12.5% of those 65 or over.