The Hannibal Micropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of two counties in northeast Missouri, anchored by the city of Hannibal.

[1] As of the census[2] of 2000, there were 37,915 people, 14,802 households, and 10,307 families residing within the μSA.

The racial makeup of the μSA was 94.45% White, 3.73% African American, 0.25% Native American, 0.23% Asian, 0.06% Pacific Islander, 0.14% from other races, and 1.14% from two or more races.

Hispanic or Latino of any race were 0.78% of the population.

Males had a median income of $29,537 versus $20,415 for females.