The church and the rectory are listed on the National Register of Historic Places and are also Omaha Landmarks under the St. Philomena name.

The Spanish Renaissance Revival style church was built in 1908 as St. Philomena's Cathedral.

The church was designed by Omaha architect Thomas Rogers Kimball.

The name of the church was changed in 1958 to honor the first American citizen to be canonized a saint, Frances Xavier Cabrini.

It was named an Omaha Landmark in 1979 and it was added to the National Register in 1980.