St. Rose is on the east bank of the Mississippi River, two miles (3 km) north of the Jefferson Parish border and is part of the Greater New Orleans metropolitan area.

The plantation was based on the cultivation and processing of sugar cane and was dependent on slave labor.

One of the few buildings left on the property after the Civil War was the dependency house, also called a garconnière (French for bachelor quarters).

In 1880, Elkins invited freedmen and their families to move onto his property to receive training.

As of the 2020 United States census, there were 7,504 people, 2,914 households, and 1,905 families residing in the CDP.