In the middle 17th century galleries were added and the interior was remodelled in the Baroque fashion.

Some of the old interior undamaged includes the Shrine of St. Sebaldus, works by Veit Stoss and the stained glass windows.

The modified case was destroyed by the Allied forces during a bombing raid on 2 January 1945.

Organists who worked at St. Sebaldus include the following (almost all held the post until their death, except where stated otherwise): The church features a Judensau, an antisemitic sculpture depicting Jews engaged in obscene activities with pigs.

A third Jew is feeding the sow on the left side, while a fourth is collecting the excrement on the right.