The present building was dedicated in 1952 by Archbishop Michael of America; the church's previous building was demolished and the congregation worshiped in the nearby Ft. George Presbyterian Church during construction.
[1] In the mid-20th century, the neighborhood was home to large numbers of Greek immigrants.
[2] By the end of the century, the population of the neighborhood had changed, the congregation was dwindling, and the church was failing financially.
[2][3] The parish also operated the adjacent St. Spyridon School, which was similarly failing for lack of funds by the end of the century.
[6] The interior is noted for the elaborate, traditional iconography that covers the walls and ceilings, much of it was created when the church was built by Georgios Gliatas, a student of iconographer Fotis Kontoglou.