Mother Marie Louise De Meester (born on April 8, 1857, in Roesalare, West Flanders, Belgium) and her novices arrived on the shores of Tagudin, Ilocos Sur on June 21, 1910.

Tagudin became the base of the ICM missionary work throughout the Philippines which gave birth to institutions of learning in the country including the different campuses of St. Theresa's College.

World War II wrought havoc on the St. Theresa's College campus in San Marcelino, Manila, leaving it in ruins.

The parcel of land was part of the Hacienda de Tuason, one of the properties acquired by the Tuazon family during the colonial period.

The STCM was a well-known exclusive all girls school attended by mestizas (mixed native and European Spanish ancestry) and their children.

After World War II, the school has been re-oriented to focus on primary to secondary education and phasing out its college courses, and opened its doors to accommodate an ever-growing population of students.

A rudimentary makeshift building used by the U.S. Army, which previously occupied the place, as a garrison to protect the area, was utilized temporarily for the classrooms of St. Theresa's College, Quezon City, and for the quarters of the ICM sisters.

An ICM Sister was then commissioned to prepare a program for St. Theresa’s College, Quezon City which called for the school to make available the educational program to deserving families from the lower - middle income group by way of tuition discount, subsidized by Sambayan Educational Foundation, Inc. (SEFI), the funding arm.

In June 2016 DepEd launched the senior high school (SHS) program nationwide, a new level of basic education consisting of grades 11 and 12 (K-12).

SINAG (or Socialized Instructional Activities for the Advanced Group) in Science, Mathematics, Performing Arts, and Creative-Writing helps students enhance their potentials in various subjects.

The inscription around the seal reads Virtute, Scientia, Artibus Floreat - which is Latin for "education in and through virtue, science, and the arts."

The seal is a badge showing the mountain peak of Carmel, linked with the school's patron saint, St. Teresa of Avila, the first woman doctor of the Church.

The Family council celebrated their Golden Jubilee in 2011 The Sambayan Educational Foundation, Inc. or SEFI was organized in 1972 by the Missionary Sisters of the Immaculate Heart of Mary (ICM) and a group of STCQC parents and alumnae which called forth the school to make available the educational program to deserving families from the lower-middle-income group by way of socialized tuition fee.