It is a part of the Hamilton-Wentworth Catholic District School Board and is located on the west side of the Hamilton Mountain.

The Senior Knights are consistently among the highest ranked football teams in Canada.

[7] St. Thomas More is a long-standing, provincial power in girls' basketball at the senior varsity level.

The program has won league titles in 1988, 1989, 1991, 1994, 2003, 2004, 2007, 2008, 2013 and 2014 as well as capturing 4 OFSAA "AAAA" gold medals in 2004, 2011, 2012, 2013.

Their long-time, main league rival is St. Mary CSS, who is also considered to be an elite level program with multiple OFSAA titles.