On November 18, 1918, the Ladies of Charity, an organization of Catholic women, established St. Vincent's Day Nursery in response to a growing need for quality care for children of working mothers.
Sister Lucia Dolan, a Daughter of Charity, joined the Day Nursery staff six months later in May 1919.
[citation needed] In 1936, St. Vincent's became a member agency of the Community Chest in Evansville through Catholic Charities.
On October 14, 1998, Ground-breaking ceremonies were held to mark the beginning of remodeling and expansion of the newly acquired building.
Designed by architects from 31 Engineering and constructed by Deig Brothers, this addition provides 12 classrooms on the first floor.