It was opened during the extension of the Nahe Valley Railway from Idar-Oberstein via Türkismühle to Neunkirchen (Saar) on 26 May 1860.

Wendel–Neunkirchen (Saar) section of the Nahe Valley Railway from Bingen am Rhein to Saarbrücken on 26 May 1860.

A single-track local railway was opened from St. Wendel station to Tholey on 3 August 1915, but its planned continuation to Lebach was not built.

Meanwhile, the entire line from St. Wendel to Tholey has been converted to an asphalt long-distance cycling route (Wendelinus–Radweg).

The station is a stop of an hourly Regional-Express line RE 3 from Frankfurt (Main) Hauptbahnhof or Mainz Hauptbahnhof to Saarbrücken Hauptbahnhof and an hourly Regionalbahn service from Neubrücke via Türkismühle, St. Wendel and Neunkirchen to Saarbrücken (RB 73) and an hourly Regionalbahn service from St. Wendel via Neunkirchen to Saarbrücken (also RB 73).