St. Wendelin was home to many good sports teams over the years, including a great Girls Basketball run that included back to back State Final Four appearances and one State Championship appearance.

They competed in cross country, golf, volleyball, basketball, wrestling, track, softball, and baseball.

Due to issues with numbers and competitive balance, St. Wendelin's football team dropped out of the MAL after the 2008 season and played in the Northwest Central Conference for 2009 and 2010.

They were then asked to leave the NWCC after canceling multiple games and began competing in the Lansing, Michigan-based Christian Athletic League of America in 2011.

[3] The primary concerns were finances and a dwindling enrollment (one-third of its 100 students at the time were graduating seniors).