However, unlike other parts of the future American Midwest, there were no attempts to found Catholic missions in Ohio.

After the American Revolution ended in 1783, Pope Pius VI erected in 1784 the Prefecture Apostolic of the United States, encompassing the entire territory of the new nation.

Schrembs requested that the Sisters of Saint Francis of Rochester, Minnesota, send nuns to Toledo to work with Polish immigrant children.

During his tenure as bishop, Stritch established Mary Manse College in Toledo in 1922 and incorporated the diocesan Catholic Charities in 1923.

He also began construction of Holy Rosary Cathedral, whose cornerstone was laid by Cardinal János Csernoch in 1926.

[10] In 1967, he issued a pastoral letter endorsing open housing ballot initiative, which was defeated in a city referendum that fall.

[11] He also established the Diocesan Development Fund and special programs for Spanish-speaking, African American and elderly Catholics.

Hoffman died in 2003 and was replaced by Auxiliary Bishop Leonard Blair of Detroit, named by John Paul II.

2005, Blair directed the Sisters of St. Francis to cancel a three-workshop by New Ways Ministry at the order's campus in Tiffin.

[12]Reverend Gerald Robinson was convicted in 2006 of the 1980 murder of Sister Margaret Ann Pahl at Mercy Hospital in Toledo.

[13] In July 2011, Blair told parishes and parochial schools in the diocese not to raise funds for the Susan G. Komen Foundation.

[18] In August 2020, the Federal Bureau of Investigation (FBI) arrested Reverend Michael Zacharias, a diocesan priest, on charges of sex trafficking, coercion and enticement.

[19] He introduced his victims to pain medications and heroin, then convinced them to engage in prostitution once they had developed drug dependencies.

[20] In September 2020, the Toledo Blade reported that there were flaws in the diocese's efforts to combat sex abuse, such as the lack of psychological evaluations.

The formal heraldic blazon is Per pale azure and gules, a tower triply-turreted, the central turret the tallest, argent, charged with a cross-humetty of the second.

[25] The Diocese of Toledo covers 8,222 square miles (21,290 km2) in the following counties: Williams, Defiance, Paulding, Van Wert, Fulton, Henry, Putnam, Allen, Lucas, Wood, Hancock, Ottawa, Sandusky, Seneca, Wyandot, Crawford, Erie, Huron, and Richland.