St Andrew High School was founded on September 21, 1925,[4] through a partnership between the Presbyterian Church and the Wesleyan Synod of Jamaica.

[5] A fund of £6,000 was initially established to found the Jamaica High School for Girls, a fee-paying institution.

Under the terms of the agreement, the school enrolled both boarders and day girls and was to be located near Kingston.

In early 1925, the parties secured the former Cecelio Lodge House on eight acres of land—with gardens, tennis courts and a hockey field—from Kingston businessman Cecil Vernon Lindo.

In 1965, the school closed its boarding facilities to create space for additional classrooms to facilitate newly introduced subjects—craft, commercial and home economics.

As of the 2018–2019 academic year, there were 1,558 students enrolled with a staff complement of ninety-five (95) teachers, including a guidance counselor and a school nurse.