In the years between the 1920s and early 1930s the missionary establishments in the southern Indian subcontinent laid foundations for a school in Hyderabad run by the church to impart education to the masses.

[1] It was, however, during the years of the partition and the formation of the nation of Pakistan (1945–1948), Archilles Meersman, a parish priest, born to a Dutch mother and a Belgian father, at the Franciscan seminary at Karachi, built the new school.

[4] The Catholic Board of Education took charge of the development and running of the school and erected a church in the memory of Saint Francis Xavier for his services in Central Asia and India.

Running under a Christian administration, the schools imparted education to upper and middle-class students until the 1970s when these were nationalised and taken over by the socialist government of Zulfiqar Ali Bhutto.

With its significant growth in educational services, Aga Khan University extended an offer for affiliation in 2007 for curricular material to be introduced to enable the school to attain the status of a college.

Annual competitions include debating (English, Urdu, Sindhi), elocution (English, Urdu, Sindhi), CSE (AKU-EB Section), science exhibition, singing competition, computer quiz and exhibition, and drawing contest.