The second church was completed in 1842 and became the first cathedral, as Bishop (William Piercy Austin) was consecrated and the Diocese of Guiana created on 24 August 1842.

It was in the Gothic style of architecture, complete with flying buttresses, but it also had a tropical flavour, ensuring light and air.

However, it was to be in timber and the committee emphasised that "woods of the country and no others were to be used", although in fact pitchpine was imported from North America for the ceiling.

St. George's Cathedral is characterised mainly by Gothic arches, clustered columns and flying buttresses.

The brass lectern, near the central altar, was given by the Diocese of Barbados when the present cathedral was opened in 1892.

The wooden Centenary Cross in front of the high altar marks the 100th anniversary of the Province of the West Indies, founded in 1883.