As a major tertiary and teaching hospital, St George accepts patients from other parts of Sydney, NSW and beyond.

The hospital is also the nearest provider of specialist medical services for around 200,000 residents of the Sutherland Shire.

[3] Hon J. H. Carruthers, Minister for Lands, outlined the necessity for the hospital and discussed fundraising efforts, including a day of racing at Moorefield Racecourse.

J. H. Carruthers presented a funding plan based on charitable efforts, highlighting the statistics of patients from the area admitted to other hospitals and emphasising the potential benefits of a local facility.

[4] Subsequently, committees initiated their project efforts, and the site selection process was entrusted to representatives from the municipalities and medical professionals, with Dr Manning acting as an arbitrator.

In the late 1980s, it underwent a A$200 million redevelopment into a tertiary teaching hospital, providing the people of southern Sydney with specialist healthcare services closer to home.

The building includes a 52-bed intensive care and high-dependency unit (with 38 funded beds), a cardiac catheterisation unit, 128 inpatient beds, a sterilising services department (SSD), an atrium linking to the ED, the original ward block (called Tower Ward Block) and the Clinical Service Building, and 8 additional digital and interventional operating theatres.