The church was the site of the Lincolnshire Rising, starting in October 1536 and led by the vicar, who was hanged, drawn and quartered for his actions.

The weathercock was placed on the top of the spire amongst great rejoicing on the eve of Holy Cross Day, 13 September 1515.

This 'wedercoke' had been made in Lincoln from a huge copper basin captured from the Scots at the Battle of Flodden in 1513.

In October 1536, as a result of Henry VIII's ecclesiastical changes, people gathered in the church to start the Lincolnshire Rising, which was followed by the Pilgrimage of Grace.

Neither succeeded and the church was stripped of its riches, including the rood screen, by the king's forces.

A new heating system by Hayden and Son of Trowbridge was installed with the boiler in a newly constructed vault.

A stained glass window, the gift of J. L. Fytche, was fixed on the east end of the south aisle.

Another window, by Clayton and Bell, was to be placed at the west end of the north aisle, in memory of General Sir George Patey.

[8] In 1937, the church flew the highest flag in Lincolnshire to mark the coronation of George VI.

[9] In 2015 researchers discovered two pieces of a pre-Conquest standing Stone Cross, dating to c950, in the Rectory garden.

The Cross and its implications for the archaeology, history and the early church in Louth are discussed in a major article by Everson and Stocker, "{'}The Cros in the Markitte Stede'.

Substantial records exist in the churchwardens' accounts from 1501 onward for the construction and use of the wheel, which was to become known as The Wild Mare.

In the Middle Ages, this saint was the focus of a major pilgrimage route to Santiago de Compostela in Spain.

In 1859 the income of the vicarage was augmented by an Order in Council by amalgamating it with revenues of the associated canonry of Lincoln Cathedral, the benefice becoming a rectory in its own right.

[15] When this organ was worn out in 1531, it is recorded in the parish records:That the honest men of this towne of Louthe deshirying to have a good payr of organs, to the laude, prayse and honour of God, and the Hole, Holy Co’pany of heffen, made an assemble together for this purpose on a certayne daye; at which type Mr. Richard Taylor, preste and bachelor of laws, then abydyng w’tin the dyocess of Norwiche being p’sent, herying the good devoute mynds, and vertuouse intent of the said townesmen, wherin he was borne and brought up, offred for to cause them have a payr made of a c’nnyng man in Lyn, that should be exampled by a payre of the same making at Ely, who was called Mr. Blyton, which then had a singular Prayse, for the sum of xxii powndes, whereof he pr’mysed to giff thereto xi powndes: upon whiche promesse they accorded, insomuch that the said Mr. Taylor covennantyd and bargaynyd the organ to be made and brought to this towne, and set upon the north syde in the hihhe quere, on St Barnabe Eve, in the yere of oure Lorde, M.V.