The St Luke's Workhouse stood on City Road between Wellesley Terrace and Shepherdess Walk in the parish of St Leonard Shoreditch, today the London Borough of Hackney.

Initially, the workhouse was located on the north side of Featherstone Street, Bunhill Fields, it having opened in 1724.

In 1930 it was taken over by the London County Council and was renamed the St Matthew's Hospital in 1936.

World War II bomb damage destroyed the southernmost block, which was never fully repaired.

[1] The vestry hall was sold to the London and Provincial Assurance Company before being demolished in the 1960s.