[citation needed] Mackillop College accepts students from year 7 to 12.

These houses – Mindygari, Meup Meup, Gurabang and Ngadyung – represent the four classical elements, with names derived from the language the Ngunnawal people, the local Aboriginal people.

[1] Sister Noeline Quinnane, a member of the religious order founded by the college's patron, Mary MacKillop, was the founding principal of St. Mary MacKillop College, serving from 1997 to 2003.

Moria Najdecki left at the end of 2006 to take up the role of Director of the Catholic Education Office.

[2] Michael Lee succeeded Rita Daniels as principal beginning in January 2008, having previously held positions at Hennessy Catholic College and Mt.