It is closely associated with the nearby Hughenden Manor and the former Prime Minister of the United Kingdom, Benjamin Disraeli who is buried in the churchyard.

[5] Royal protocol did not permit Queen Victoria to attend the private funeral, but she visited the tomb a few days later to pay her respects.

The ornately carved marble and alabaster pulpit (c. 1891) is the work of Thomas Earp in the High Victorian style and features effigies of archangels in Gothic arches.

[8] St. Michael and All Angels' Church featured in the title sequence of Gerry Anderson's 1969 Supermarionation/Live Action television series The Secret Service.

It also featured briefly in the film Johnny English, in the funeral scene where a bomb kills all of Britain's secret agents.