It is on the East Coast Main Line, about 52 miles (83 km) from London King's Cross.

The first section of the Great Northern Railway (GNR) - that from Louth to a junction with the Manchester, Sheffield and Lincolnshire Railway at Grimsby - opened on 1 March 1848, but the southern section of the main line, between Maiden Lane and Peterborough, was not opened until August 1850.

St Neots station has automatic ticket barriers, which were installed in 2008 by former franchise holder First Capital Connect.

These services run non-stop between Stevenage and London King's Cross and are operated by Great Northern using Class 387 EMUs.

[7] In the chainage notation traditionally used on the railways, the station is 51 miles 58 chains (83.24 km; 51.73 mi) from London King's Cross.