St Spyridon College is a dual-campus independent Greek Orthodox primary and secondary school, in the eastern suburbs of Sydney, New South Wales, Australia.

Established in 1983, the College enrolled approximately 750 students in 2019, from Kindergarten to Year 12, of whom no students identified as Indigenous Australians and 83 percent were from a language background other than English.

[1] Administrative oversight of the school is managed by the St Spyridon Parish and Community of South East Sydney[2] in accordance with a curriculum developed by the New South Wales Education Standards Authority.

The principal of the high school campus is Amelia Katsogiannis.

This article related to a New South Wales school is a stub.