She attended the University of California, Berkeley with initial plans of becoming a criminal defense attorney, but along the way reevaluated her direction and shifted focus to Mass Communications.
After college, Littlejohn relocated to Los Angeles where she worked as a PA on Fox's The Last Frontier before securing a job as a writer's assistant to Matt Wickline and John Bowman on The Show.
She then worked on the sitcom Moesha for a brief stint before Wickline offered her a job writing for a show he was creating for D.L.
Littlejohn next worked on such shows as One on One, Life with Bonnie, Platinum, Cedric the Entertainer Presents and Barbershop.
Producer Maggie Malina of VH1, who was working with Queen Latifah's Flavor Unit in search of the right project, read the script and asked Littlejohn to pitch a show.