It was built between 1770 and 1776 and designed by Friedrich August Krubsacius using a mixture of baroque, rococo and classical elements.
Twenty media stations also provide information about Dresden's development over the last 800 years.
The scientific collection is extensive and includes objects related to the culture, history of, and daily life in the city.
Of particular note are the more than 1000 photographs of the city and its personalities dating from the middle of the 19th century to around 1930.
These include objects relating to interior decoration, household management, clothes, militaria, musical instruments, toys, medals and coins, machines, instruments and applied arts.