Central to the program is a telethon that was first televised by four major broadcast networks (ABC, NBC, CBS, Fox) in over 170 countries on September 5, 2008.
Current members of the SU2C Council of Founders and Advisors (CFA) include Katie Couric, Sherry Lansing, Kathleen Lobb, Lisa Paulsen, Rusty Robertson, Sue Schwartz, Pamela Oas Williams, and Ellen Ziffren.
The campaign has featured televised moments during World Series baseball games where fans literally "stand up to cancer" by rising and holding signs inscribed with the names of friends and loved ones who have struggled with the disease.
The research is required to be translational and include laboratory and clinical members and cannot involve more than one principal investigator from each institution.
This event was aired on more than 70 broadcast and cable networks and streaming and social platforms, including: CBS, HBO and NBC.
[15] In Canada, the 2014 telethon aired September 5, 2014 in simultaneous substitution (in many areas) with the American telethon, simultaneously on English language networks CBC Television, City, CTV and Global, as well as CHCH-DT in Hamilton, Ontario, CHEK-DT in Victoria, British Columbia, CJON-DT in St. John's, Newfoundland and Labrador, and specialty channels TLN, Fight Network, Gusto TV, AMI-TV and the Hollywood Suite channels.
On 19 October 2012, Channel 4 in the United Kingdom aired their first telethon for Stand Up to Cancer hosted by Davina McCall and Alan Carr along with Dr. Christian Jessen.
The most recent one was held on 15 October 2021,[18] and was hosted by Alan Carr, Adam Hills, Maya Jama and Davina McCall.