The Shire of Stanthorpe was a local government area of Queensland, Australia on the Queensland-New South Wales border.

Its main industries included fruit and vegetable growing, wineries and tourism, and sheep and cattle grazing.

The Shire, administered from the town of Stanthorpe, covered an area of 2,697.6 square kilometres (1,041.5 sq mi), and existed from 1879 until 2008, when it amalgamated with the Shire of Warwick to become the Southern Downs Region.

[4] On 15 March 2008, under the Local Government (Reform Implementation) Act 2007 passed by the Parliament of Queensland on 10 August 2007, the Shire of Stanthorpe merged with the Shire of Warwick to form the Southern Downs Region.

The Shire of Stanthorpe included the following settlements: * - acquired its name from one Private E Cotton a local who enlisted in the Australian Air Force